The global incidence of Cancer is scoring due to rapidly aging population in most countries. By the year 2020, there will be 20 million new cancer patients each year.

Of the million people who get cancer every year in India, the vast majority is incurable at the time of diagnosis. At least two third of them get pain, vomiting, dysponea, fungating wounds and host of other symptoms add to their misery. In additional social, financial, emotional and spiritual factors compound their problem. They need pain relief and palliative care.

Surviving and living longer is not an ultimate aim for most of the cancer patients. They need to be made comfortable to carry out everyday activity without physical fuse and emotional fissure therefore, they must be rehabilitated, made aware and thought how to improve strength, endurance and ability to overcome and compensate for certain neurological, muscular and psychological deficits.

AIMS & OBJECTS:

Plants are sophisticated organisms consisting of thousands of organic compounds. Several new plant derived natural products have proved to be of extreme interest in the treatment of cancer. In radiotherapy radiation particles are aimed at the tumor to cause damage in the cells of the tumor. However, because of the location of the tumor, it is impossible to avoid some damage to the normal cells that are in the path of radiation beam.

The overall objective of this study is to compare the efficacy of radiotherapy plus herbal therapy in previously untreated oral cavity and cervical cancer. Important efficacy endpoints will be objective tumor response rate, duration of response, proportion of patient with early progressive disease or early response-stable disease.

Thus to increase the locorigional control and disease free survival, to combat the side effect of the radiotherapy and most important aims to provide and agent to increase the radiation effect by this concomitant Radio-herbal protocol.

MATERIAL AND METHOD:

Aswagandha (WITHENIA SOMNIFERA) mool extract in dose of 5 Gm. per day with milk before external radiation (conventional RT.) in 100 patients of oral and cervical carcinoma..

INCLUSION CRITERIA:

It was mainly based on the signs & symptoms of Arbuda described in Ayurvedic classics as well as in modern texts after confirming the investigation reports like biopsy, FNAC etc. Head & Neck cancer of 3rd and 4th stage and cervical cancer of III-B and above will select.

The selected patients have been divided into 2 Groups:

GROUP A : Radiotherapy plus placebo.

GROUP B : Radiation plus Aswagandha.

Plan of study was divided in two arms: -

PATIENT ENROLLMENT FORM:

Patient enrolment form must be completed for each eligible patient. This form must be completed before the study drug is given to the patient. This form will contain information regarding the patient’s eligibility before a patient can be randomized

Investigation: -

[a] Routine investigation :
For the purpose of assessing the overall condition of the patient, routine investigation of blood, urine, stool & biochemical investigation whenever necessary.

[b] Special investigation :
All the patients included in present study will biopsy proved. Relevant radiological and clinical examinations will carried out for any other kind of pathology.

DRUG SCHEDULE:

DRUG NAME : Aswagandha mool
FORM : Extract (in tablet form)
DOSE : 5 Gm. With milk :30 minuites before external radiation.

PHARMECOKINETICS:

The main property of Aswagandha is a natural Anti-oxidant which helps to increase the moleqular effect of radiation. Thus this drug acted both directely on cancer cells and by making them more sensitive to Radiotherapy.Aswagandha helps to decrease the amount of Glutathione in tumor cells after which radiation therapy become more effective.

DIETARY SCHEDULE:

On the basis of an exploratory study a detailed case control investigated was initiated at the TMH-Tata Memorial Hospital to explore the role of diet in Head & Neck cancer.

Among the several food items considered, some showed protective effect, One was with respect to vegetable consumption. It was observed that those who did not eat vegetables daily were at a significantly higher risk. So, every patient will advised to take vegetables & fruits.

Intake of buttermilk & milk also showed protective effect with a 3-fold risk in those who did not intake it daily versus those who did. So, patients will advise to take it daily.

Laboratory observations suggest that vitamin-A; Beta-carotene, Vitamin-C & fiber have protective effect in Head & Neck cancer. So, carrots & other vegetable where vitamin-A and increase fiber are present are advised specially to the patients. Every kind of addiction were restricted & specially advised for maintain good oral hygiene.

PROGRESS: -

Once the treatment will started, the patients will weekly examined for vital sign, symptoms and for overall condition. Weekly progress will record upto total radiation and final assessment for the efficacy of the drug will carried out.

RESPONSE TO THERAPY:
Find good objective response. About 80% of the patient had completely regress the tumor without any side effects.

Author's Bio: 

BIO-DATA

NAME: Dr. BHAVNA P. BHUT

CITIZENSHIP: INDIAN

HOME ADDRESS: LOHANA PARA, JAYANT NIVAS,
RAJKOT-360001.
GUJARAT. INDIA.

HOSPITAL ADDRESS: ?OJAS?AYURVEDA THERAPY CENTER
AND CANCER CARE HOSPITAL AND RESEARCH CENTER, 301- SHILJA SHANKUL, RAIYA
ROAD, RAJKOT-360001.GUJRAT. INDIA.

CONTECT NO.: 91-0281-235053==RESI.

91-0281-458743==HOSP.

E-MAIL:
bhav@ad1.vsnl.net.in

DATE & PLACE OF BIRTH: 4-11-70 RAJKOT. (GUJARAT-INDIA.)

LANGAUAGES KNOWN: GUJARATI, ENGLISH and HINDI.

QUALIFICATION:

S.S.C.: 1986 FROM DEVKUVRBA HIGH SCHHOL,
RAJKOT. GUJARAT.

H.S.C.: 1988 FROM KADVIBAI HIGH SCHOOL,
RAJKOT. GUJARAT.

B.A.M.S. (BACHLOR OF AYURVEDIC MEDICINE & SURGERY) FROM JAMNAGAR
AYURVEDA UNIVERCITY ?APRIL 1993 from Araya Kanya college - Baroda.

INTERNSHIP: DEC-1993 AT JAMNAGAR AYURVEDA
UNIVERCITY.

M.E.T.C.: i.e. (medical emergence treatment course) 1994 from
Rajkot civil hospital.
M.D. (AYURVEDA IN ONCOLOGY) FROM JAMNAGAR
AYURVEDIC UNIVERCITY ?DEC.1998.

YOGA EDUCATION UPTO MADHYAMA.

COMPUTAR EDUCAITON UPTO WINDOW?8 AND INTERNET.

WORK EXPERIENCE:
I completed my M.D. research work at Nathalal parekha cancer hospital &
research center, Rajkot in 1997-1998, which is the collaborative center
for the Jamnagar Ayurveda University. I work their for one and half
year under guidance of Dr. V.K.Gupta-Medical Director and chief Radiation
Oncologist. Which give me best experience regarding cancer in all
aspects vis. Sx, RT, CT, Brachy therapy and combined modality of the
therapy, palliative treatment and preventive Oncology.
OTHER ACIVITY:

PRESSENTLY COLLABORATION WITH LIONS CANCER HOSPITAL, SURAT UNDER
GUIDANCE OF Dr. S.P.SHREEVASTAV ( MEDICAL DIRECTOR AND CHIEF RADIATION
ONCOLOGIST) FOR COMPARATIVE STUDY TO COMBACT THE SIDE EFFECT OF RADIOTHERAPY
AND TO INCREASE THE EFFECT OF RADIOTHERAPY IN ADVANCE HEAD & NECK
CANCER AND CERVICAL CANCER WITH RADIATION AND PLANT PRODUCT.

PAPER PRESENTATION AND PUBLICATION:

GOLD MEDAL IN INTERNATIONAL SEMINAR ON AYURVEDA AND CANCER ?997 AT
PUNE.

NATIONAL SEMINAR ON AYURVEDA AND CANCER ?998 AT DELHI.

NATIONAL CONFERENCE IN RAJYOGA AND MEDITATION RETRITE AT MOUNT ABU
?999 BY GLOBLE HOSPITAL.

NATIONAL SEMINAR ON AYURVEDA AND CANCER ?999 AT JAMNAGAR

GOLD MEDAL IN INTERNATIONAL SEMINAR ON CANCER AND AYURVEDA AT
JAMNAGAR AYURVEDA UNIVERCITY IN JAN.2000.